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When acid isn't the answer

Heartburn That PPIs Don't Fix

You've taken the acid-blockers for months and the burning is still there. When PPIs don't work, it's often because the problem was never really acid.

When it's not acid, it's sensitivity

In functional heartburn and reflux hypersensitivity, the esophagus has become over-sensitive: normal or near-normal amounts of acid and ordinary swallowing are perceived as burning pain. That's why suppressing acid further doesn't help — there isn't excess acid to suppress.

The brain-gut connection

This esophageal hypersensitivity is part of the same brain-gut signalling family as IBS and functional dyspepsia. The nerves carrying signals from the gut to the brain are turned up too high, amplifying normal sensations into pain.

What helps when PPIs don't

Gut-directed therapies — including gut-directed hypnotherapy, CBT and ACT — and certain neuromodulators target the hypersensitivity directly. For many people whose reflux didn't respond to acid suppression, this is the missing piece. Always keep your physician involved to rule out other causes first.

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Frequently asked questions

If PPIs didn't work, what's going on?
Often the issue is an over-sensitive esophagus rather than excess acid, so acid-blockers can't help. That sensitivity is treatable through the brain-gut axis.
Do I stop my reflux medication?
Never change medication without your physician. We work alongside your medical care, not instead of it.
Can this be treated in Manitoba virtually?
Yes — we provide virtual gut-directed care across Manitoba, with self-referrals welcome.

This article is educational and is not medical advice. For diagnosis and treatment, speak with a qualified clinician.

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